What if pain in fibromyalgia is primarily due to increased muscle tension?

Robert S Katz1*, Frank Leavitt2, Ben J Small3

1Section of Rheumatology, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA

2Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA

3Department of Rheumatology, Northwestern Memorial Hospital, Chicago, IL, USA

We have found, using a pressure gauge with a needle inserted into the trapezius muscle, that muscle pressure is almost three times higher in patients with the fibromyalgia syndrome (FMS) compared with rheumatic disease and normal controls1. The trapezius muscle was chosen for convenience. In the future the quadriceps and other muscles will be evaluated. Rheumatic disease patients with conditions other than fibromyalgia were chosen because they tend to have some musculoskeletal pain but generally much less than fibromyalgia patients.

The muscles are painful in fibromyalgia, and tender points used to be a part of the criteria for the diagnosis. The American College of Rheumatology’s current criteria2, however, have not included tender points. The new criteria for fibromyalgia are entirely subjective, and despite the best exercise of professional judgement, leave room for interpretation.

The quantitative measurement of muscle pressure has a significant benefit in the diagnosis of FMS. It can be determined by a doctor or nurse in the office and recorded as numerical data. The differences observed in the muscle pressures of patients with and without fibromyalgia were found to be significant (p< 0.001).

Past muscle biopsies of fibromyalgia patients have shown evidence of hypoxia in skeletal muscle, but no inflammation3,4,5. Is the hypoxia due to increased muscle tension with compression of the microvasculature?

Another observation that might relate to increased muscle pressure is the straight neck seen on lateral view radiographs of the cervical spine6,7. When observing the neck x-ray of a patient with fibromyalgia, a loss of the usual lordotic curve without other radiographic abnormalities can typically be found. Instead of a reverse C, the neck looks straight, a potential effect of the high muscle pressure found in patients with FMS. A lateral view of the cervical spine may be a diagnostic ais in fibromyalgia and not require an evaluation of muscle pressure.

It will be interesting to evaluate noninvasive techniques for measuring muscle pressure, and currently elastography (shear wave ultrasound) and near infrared spectroscopy are two possible technologies to look for muscle firmness (shear wave ultrasound) and for hypoxia (infra-red spectroscopy, similar to pulse oximetry).

If fibromyalgia patients do have increased muscle pressure, as our research suggests, there is still a central component to the pain. We have evaluated anxiety and stress8,9, both of which appear to make the muscle pain worse in fibromyalgia, according to patients surveyed. These patients could be neurologically ‘wired’ in a way that predisposes them to chronically tense their muscles.

Approaches to reduce the pain in fibromyalgia can include medications like muscle relaxants as well as other non-pharmacologic techniques such as meditation or other relaxation strategies10,11 to reduce muscle tension. High doses of cyclobenzaprine or tizanidine at night to avoid daytime sedation, in addition to amitriptyline and similar medications also at night to improve interrupted sleep, may be helpful. Explaining to patients that they may be unconsciously tightening their muscles can help them focus on muscle relaxation and try to divert their attention away from their significant pain throughout the day.

Further research needs to be done to understand the role of increased muscle pressure and its contribution to the pain in fibromyalgia. Using muscle pressure as a quantitative marker with the aid of a pressure gauge may help us to recognize increased muscle tension as an important mechanism.


  1. Katz RS, Leavitt F, Small AK, et al. Increased pressure in the trapezius muscle may be a mechanism for understanding pain in fibromyalgia. The Journal of Rheumatology. 2021; 48(4): 598-602.
  2. Wolfe F, Clauw DJ, Fitzcharles MA, et al. 2016 Revisions to the 2010/2011 fibromyalgia criteria. Seminars in Arthritis and Rheumatism. 2016: 46(3): 319-329.
  3. Bengtsson A. The muscle in fibromyalgia. 2002; 41(7): 721-4.
  4. Bengtsson A, Henriksson KG. The muscle in fibromyalgia—a review of Swedish studies. Journal Rheumatology. 1989; 19: 144-9.
  5. Yunus M. Muscle biopsy findings in primary fibromyalgia and other forms of non-articular rheumatism. Rheumatic Disease Clinics of North America. 1989; 15: 115-34.
  6. Katz RS, Leavitt F, Cherney K, et al. A vast majority of patients with fibromyalgia have a straight neck observed on lateral view radiograph of the cervical spine: An aid in the diagnosis of fibromyalgia and a possible clue to the etiology (in press).
  7. Helliwell P, Evans P, Wright V. The straight cervical spine: Does it indicate muscle spasm? Journal Bone and Joint Surgery. 1994; 76: 103-6.
  8. Katz RS. The Effect of Anxiety on Fibromyalgia Symptoms (in press)
  9. Katz R, Katz-Small A, Small B. The Effect of Perceived Stress on Pain Levels in Fibromyalgia Patients
  10. Anheyer D, Haller H, Barth J, et al. Mindfulness-based stress reduction for treating low back pain: A systematic review and meta-analysis. Annals of Internal Medicine. 2017; 166(11): 799-807.
  11. Scott J, Hassett A, Schrepf A, et al. Moderate alcohol consumption is associated with reduced pain in fibromyalgia symptoms and chronic pain patients. Pain Medicine. 2018; 19: 2515-2527.

Article Info

  • Journal of Anesthesiology and Pain Therapy
  • Article Type : Commentary
  • View/Download pdf

Article Notes

  • Published on: December 02, 2021


  • trapezius muscle
  • fibromyalgia syndrome (FMS)
  • rheumatic disease
  • microvasculature
  • elastography


Dr. Robert S Katz,
Section of Rheumatology, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA; Telephone No: 312-226-8228;
Email: rkatzchil@gmail.com

Copyright: ©2021 Katz RS. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.